Since their discovery, we learned that the microglia immune status is often correlated directly to their morphology. However, only recently, have we realized that, in vivo microglia are extremely dynamic cells capable to respond within minutes. Therefore, the name resting microglia is replaced slowly with surveilling microglia. These may be related to the role played by epithelial-mesenchymal transition EMT and cancer stem cells in endometrial carcinogenesis.
In this context, our review highlights the prognostic significance of several types fingers predict prostate cancer myoinvasion in low grade, low stage endometrioid endometrial carcinoma, as a reflection of these molecular changes at the invasive front.
According to recently introduced myoinvasive patterns, the diffusely infiltrating and microcystic, elongated, and fragmented MELF patterns show loss of hormone receptors, along with EMT and high expression of cancer stem cell markers, being associated with a poor prognosis. Additionally, MELF pattern exhibits a high incidence of lymphovascular invasion and lymph node metastases. Conversely, the broad front pattern has a good prognosis and a low expression of EMT and stem cells markers.
Similarly, the adenomyosis AM -like and adenoma malignum patterns of invasion are associated to a favorable prognosis, but nevertheless, they raise diagnostic challenges. AM-like pattern must be differentiated from carcinoma invasion of AM foci, while adenoma malignum pattern creates difficulties in appreciating the depth of myoinvasion and requires differential diagnosis with other conditions.
Another pattern expecting its validation and prognostic significance value is the nodular fasciitis-like stroma and large cystic growth pattern. In practice, the knowledge of these patterns of myoinvasion may be valuable for the correct assessment of stage, may improve prognosis evaluation and may help identify molecules for future targeted therapies.
The role of tumor microenvironment in development and progression of malignant melanomas - a systematic review Simona Gurzu, Marius Alexandru Beleaua, Ioan Jung To reveal the particular aspects of the tumor microenvironment of malignant melanomas, a systematic review including 34 representative papers was performed. The possible reversible features of EMT and the role of tumor microenvironment in the metastatic process were also analyzed.
As the McSCs embryological development in mouse is not similar to human development, the role of stem cells in genesis and development of human melanoma should be proved in human melanoma cells only. For further development of targeted therapy, a better understanding of melanomagenesis pathways and its microenvironment particularities is necessary.
Immunohistochemistry predictive markers for primary colorectal cancer tumors: where are we and where are we going?
We reviewed articles that examined CRC samples with significant statistic correlation between the IHC marker expression and disease progression over time, relationships with the available clinical features and those who detect the prognosis of drug effects. Our analysis showed that nine markers could correlate with medical treatment response of CRCs in different stages.
When using better overall survival OS and better disease-free survival DFS as a grouping factor, there were 14 markers that could be used in assessing CRC prognosis. Subgroup analysis was also performed based on the 32 markers recently confirmed to predict fingers predict prostate cancer evolution or the recurrence risks. Venous invasion could be predictable for fingers predict prostate cancer, statistically significant metastasis susceptibility was observed for markers and also the capacity to evaluate recurrence.
CRCs integrate a variety of localizations and there are proofs that fingers predict prostate cancer the sites of tumors.
The studies reporting data specifically for rectal cancer separating it from colon cancer contained seven IHC markers.
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In order to be able to implement a predictive biomarker in clinical practice, it must comply with certain criteria as clinical value and analytical proof. Unique biological signature of CRC can be distinguished by identifying biomarkers expression. Several markers have shown potential, but the majority still need to render clinical utility. Cum să tratezi prostatita cronică congestivă prostatic cellular and molecular kaleidoscope.
Starting points for carcinogenesis Andrei Daniel Timofte, Irina-Draga Caruntu The prostate cancer is a heterogeneous disorder concealing different phenotypical and functional subtypes fingers predict prostate cancer cancer cells. This heterogeneity mirrors the normal prostate cell lineages whose alterations represent the starting points of the carcinogenesis mechanism.
The histological structure of the prostate comprises two main types of cells: epithelial and stromal, with a stromal to epithelial ratio of The prostate acini are lined by a contiguous layer composed of four different subtypes of epithelial cells: secretory luminal, basal, neuroendocrine, and transit-amplifying. The epithelial component is enclosed in a stromal tissue, consisting of several types fingers predict prostate cancer cells: smooth muscle cells the most numerous cell typefibroblasts, and myofibroblasts.
Despite their quite similar morphological appearance in light microscopy, the molecular markers expressed by the normal epithelial and stromal prostatic components, as well as the stem cells show that the prostatic cells are not equal. Consequently, several hypotheses regarding the location and the phenotype of these cells were formulated and tested, mainly in animal models.
The molecular mapping of normal human prostate tissue might be the key for unlocking the intricate mechanisms of prostate carcinogenesis. Within this context, the prostatic cancer stem cells are thought to fingers predict prostate cancer an important role in tumor initiation, progression, recurrence and also therapy resistance.
The cancerous phenotype of a stem cell can be reached via multiple genetic trajectories and epigenetic alterations, resulting in different subclonal populations of cancer stem cells, thus explaining the heterogeneity of the prostatic neoplasia. Future efforts should be directed towards better understanding of the relationship and interactions between these cancer stem cells subpopulations, their microenvironments, and also towards characterizing the signaling pathways and molecules involved in the regulation of prostatic cancer stem cells.
The results of these studies could offer a different, more comprehensible perspective for a new, molecular classification of prostate cancer, overlapping the existing histological one. Starting points for carcinogenesis PDF 6.
It was revealed that mixing with alloying elements, such as Mn and Zn, provides improved corrosion resistance to Mg alloys; this pursuit is built on the fact that Mg and its alloys are degradable through their time fingers predict prostate cancer the human body. Furthermore, Mg alloys afford a characteristic profile that is very close or even almost identical to that of human bone.
Minimizing the rate of corrosion of Mg fingers predict prostate cancer the most adequate method, because a low corrosion rate of an Mg implant involves a decrease in the extent of hydrogen evolution and alkalization, which allow the human body to gradually absorb or consume the corrosion products. In those situations, both clinical and paraclinical findings might orientate the diagnosis, but only histological or immunohistochemistry changes might be accurate enough.
The skin histological changes are relevant and sometimes might have a tremendous role in the accurate diagnosis of autoimmune rheumatic diseases, due to the correlation with the clinical systemic manifestations of the diseases and through the accessibility of biopsy. In the same time, muscle biopsy can provide important support for physicians improving diagnosis and optimizing management of connective tissue diseases.
Correlations between morphological changes induced by curcumin and its biological activities Laura Stoica, Bogdan Alexandru Stoica, Doinita Olinici, Pavel Onofrei, Emanuela Ana Botez, Carmen Elena Cotrutz Curcumin is a phytochemical polyphenol extracted from turmeric rhizome, with multiple biological activities, intensively studied in various therapeutic areas. Its effects covers a wide range of specialties, from the neuroprotective to the antimetastatic properties, influencing pathologies from cardiovascular, neuronal and oncological fields, as a part of its broad spectrum of action.
These effects are explained by antioxidant, anti-inflammatory and anticarcinogenic simultaneous roles of curcumin and its derivatives. In this review, we selected the information about morphological evidences correlated with the biological effects on the following organ systems: the central nervous system including neurological pathology, such as Parkinson s and Alzheimer s diseasethe cardiovascular system including disorders like atherosclerosis, endothelial dysfunction and drug-induced myotoxicitymultiple forms of cancer, and metabolic syndromes including fingers predict prostate cancer.
The central point of this review was to target a variety of morphological changes at microscopic level induced by curcumin, using different microscopy techniques. Hyaluronic acid-based scaffolds for tissue engineering Cristina Chircov, Alexandru Mihai Grumezescu, Ludovic Everard Bejenaru Hyaluronic acid HA is a natural disertație prostatita found in the extracellular matrix of most connective tissues.
Due to its chemical structure, HA is a hydrophilic polymer and it is characterized by a fast degradation rate.
HA-based scaffolds for tissue engineering are intensively studied due to their increased biocompatibility, biodegradability and chemical modification. Depending on the processing technique, scaffolds can be prepared in the form of hydrogels, sponges, cryogels, and injectable hydrogels, all discussed in this review.
Sepsis is one of the most common diseases, which cause mortality and a considerable absorber of healthcare resources.
Despite progress in technology and improving knowledge of pathophysiology, the disease mechanism is still poorly understood. At present, diagnosis is based on non-specific physiological criteria and on fingers predict prostate cancer late identification of the pathogen.
For these reasons, the diagnosis may be uncertain, treatment delayed or an immunomodulatory therapy cannot be established. An early and reliable diagnosis is essential to achieve better outcomes on disease progression. The host response to infection involves hundreds of many mediators of which have been proposed as biomarkers.
There is a need for new diagnostic approaches for sepsis, new sepsis biomarkers that can aid in diagnosis, therapeutic decision and monitoring of the response to therapy. The differentiation of sepsis from non-infectious systemic inflammatory response syndrome is difficult, and the search for a highly accurate biomarker of sepsis has become one important objective of the medicine. The goal of our review is to summarize the recent advances on the most commonly studied serum biomarkers, evaluated in clinical and experimental studies, for early diagnosis of sepsis and their informative value in diagnosis, prognosis, or response to therapy.
In this context, we have tracked the clinical utility of measuring serum biomarkers, such as procalcitonin, pro- and anti-inflammatory cytokines, C-reactive protein, leptin and their combinations. Currently, has not been identified an ideal cum să faci față febrei cu prostatita to aid in the diagnosis of sepsis.
It is hoped that fingers predict prostate cancer discovery of new serum markers, as well as their combinations, will serve for the diagnosis and prognosis of sepsis. Patients, Materials and Methods: Seventeen patients were enrolled after rigorous criteria.
Echocardiography was performed in conventional and speckle-tracking mode, in all patients with DCM, in sinus rhythm. Speckle-tracking imaging was performed in offline mode and GLS was obtained from parasternal 4- 3- 2-chamber apical view, by averaging longitudinal peak systolic strain of all 17 LV-segments.
Conclusions: This study demonstrates that, in patients with DCM, assessment of cardiac dyssynchrony can be accurately accomplished by combining parameters in conventional and in speckle-tracking echocardiography. Vestibular sensory functional status of cochlear implanted ears versus non-implanted lavajul prostatitei in bilateral profound deaf adults Romica Sebastian Cozma, Lucia Corina Dima-Cozma, Luminita Mihaela Radulescu, Maria Cristina Hera, Cristian Martu, Raluca Olariu, Bogdan Mihail Cobzeanu, Oana Roxana Bitere, Mihail Dan Cobzeanu Patients with hearing loss who underwent cochlear implantation can present symptomatic or asymptomatic vestibular damages earlier or later after the surgery.
The vestibular permanent lesions could be acute, produced by surgical trauma or could be progressive due to local morphological changes made by the presence of the portelectrode in the inner ear fibrosis related, ossification, basilar membrane distortion, endolymphatic hydrops.
Besides histopathological findings in inner ear of cochlear implanted patients, the fingers predict prostate cancer permanent damages could be found by assessment of clinical vestibular status.
This study reports the sensorial vestibular functional findings for adults in cochlear implanted ears related to the electrode insertion type cochleostomy or round window approach and comparing to non-implanted deaf ears. A total of 20 adult patients with 32 cochlear implanted ears 12 patients with binaural oncologia prostatitei implant and eight with monoaural were selected for postoperatory vestibular examination by cervical and ocular vestibular myogenic potentials and vestibular caloric tests.
The same tests were made for a control group of 22 non-implanted deaf ears. Functional testing results were reported related to the electrode insertion approach. In round window group, the deficit was present in In In conclusion, the vestibular functional status after inner ear surgery presents sensorial damages in Round window insertion allows for better conservation of the vestibular function.
Cancer and aggressive behaviour
The most common histological type of cancer diagnosed in these patients is squamous cell carcinoma SCC. The treatment methods are multiple, but the optimal therapeutic option with best results on outcome and on the patients quality life has not been established. The objectives of our study were to evaluate the tongue base SCCs treated by transhyoid approach and the oncological outcomes of the surgery combined with radiotherapy. Patients, Materials and Methods: The retrospective study was performed over a period of 10 years on 37 previously untreated patients.
All the tumors were biopsied and after histopathological HP diagnosis, the tumors were excised. Results: In the study were included only the patient diagnosed on biopsy with different types of SCC. The mean age was 61 years old, most of the patients We performed a tongue base transhyoid tumor resection in 23 Bilateral neck dissections and postoperative radiotherapy were performed in all cases. The postoperative fingers predict prostate cancer post-therapeutic evolution was favorable at three years There were no signs of local or regional recurrences.
Conclusions: The prognosis for the SCC of the tongue base fingers predict prostate cancer poor. Cancer resection by transhyoid approach is a feasible procedure, which permits a good tumor control with limited postoperative morbidity, with an important benefit on the life quality of the patients.
Cancer and aggressive behaviour Rolul genei p53 în prevenirea cancerului de sân Prof. Viermi pe măsură ce apar Probleme actuale privind aplicarea protocolului de tratament în cancerul de rect Supporters and Sponsors Probleme actuale privind aplicarea protocolului fingers predict prostate cancer tratament în cancerul de rect Rolul vierme fluture p53 în prevenirea cancerului de sân - Revista Română de Medicina Familiei Media Partners Cancer and aggressive behaviour, Actual problems regarding the implementation of the treatment protocol in rectal cancer Inoperable rectal tumour, no metastases: A radio-chemotherapy with a favourable response surgery B radio-chemotherapy with a non-favourable response chemotherapy Operable rectal tumour, with cancer and aggressive behaviour radical surgery of the tumour with resection of the hepatic or lung metastasis radio-chemotherapy radio-chemotherapy followed by surgical treatment.
CRCs with MSI present fingers predict prostate cancer prognosis, a distinct histopathological aspect and a different response to chemotherapy.
The MMR proteins were analyzed using an indirect bistadial immunohistochemical IHC technique with monoclonal antibodies. All MSI tumors had a poorer histological differentiation and four cases revealed a mucinous phenotype. Eighty percent of the patients with MSI status were older women. The immunoexpression of p53 and Snail in endometrioid endometrial carcinomas Mihaela Dragomirescu, Alex Emilian Stepan, Claudiu Margaritescu, Cristiana Eugenia Simionescu Endometrial cancer is one of the most common tumors in women worldwide.
P53 has a well-known function as tumor suppressor, but it can also regulate the tissues metabolism, differentiation and development. Snail is a zinc-finger transcription factor, involved in the cell differentiation and survival.
We analyzed the immunoexpression of p53 and Snail in 55 cases of endometrioid endometrial carcinoma EECin relation with the histopathological prognosis parameters and tumoral compartments, respectively intratumoral and advancing edge areas.
For both markers, we found a statistically significant association with histological grade, in relation with tumoral compartments.
P53 and Snail can be used in developing Fingers predict prostate cancer targeted treatment. Placental defects and placental angiogenesis may be a cause of this condition.
The pregnancies included into the study for the harvesting of placental tissue to be microscopically analyzed were divided into two groups: fingers predict prostate cancer group of physiological pregnancies 22 pregnancies and the group of pregnancies complicated by preeclampsia 13 pregnancies. The microscopic aspects of HE and Masson s trichrome stainings most commonly found in normal development pregnancies underlie the normal process of placental senescence.
In the case of pregnancies complicated by PE, the microscopic analysis of the placentas revealed fibrinoid necrosis of the vascular wall, lipid-loaded endothelial cells, diffuse trophoblastic hypertrophy, microinfarctions, calcification areas, fibrin deposits, vascular-syncytial membrane surface reduction, basement membrane thickening.
The present study brings arguments that support the major regulatory role of VEGF-A and of the two receptors in the normal or pathological angiogenesis in the placenta, and implicitly in the pathogenesis of preeclampsia. Further studies are needed for a more comprehensive analysis of the stages in which these factors cause alteration of the placental angiogenesis and vasculogenesis processes, so that they can intervene effectively in the treatment or prevention of this disease.
Corresponding author: Carina Mihu, Medical Student; e-mail: carina. The purpose of this study was to histologically characterize a number of 54 patients diagnosed betweenwith tongue squamous carcinoma.
Surgical resection specimens of tongue tumors were processed by paraffin inclusion technique. The diagnose samples were reevaluated according to the World Health Organization WHO criteria for head and neck tumors diagnosis, by screening the Hematoxylin-Eosin staining sections.
The most common histopathological variety of tongue carcinoma observed in our cases was the non-keratinized form, the basaloid and sarcomatoid types fingers predict prostate cancer carcinoma being ranked on the last places. The study outlined the prevalence of non-keratinized forms of tongue squamous carcinoma and all types of tumoral invasion patterns have been observed in different percentages.
Adnexal masses in pregnancy: perinatal impact Nuti Daniela Oprescu, Cringu Antoniu Ionescu, Ioana Dragan, Andreea-Catalina Fetecau, Amira Livia Said-Moldoveanu, Raluca Chirculescu, Simona Vladareanu The incidence of adnexal masses in pregnancy has increased significantly over the last decades and this is mostly because of the widespread use of ultrasound for pregnancy surveillance.
Although a clear majority of adnexal masses found in the first trimester are functional cysts, which have a small diameter and disappear spontaneously, those that do persist into the second and third trimester require ultrasound surveillance for proper management. This is a retrospective study of all the third trimester pregnancy related adnexal masses that delivered in our Hospital in the last 10 years via C-section where cystectomy was also performed.