Maiese, Z. Chong, Yan Chen Shang, S. SIRT1 adenocarcinoma prostate gleason 33 broad biological effects that affect cellular metabolism as well as cellular survival and longevity that can impact both acute and chronic disease processes that involve neurodegenerative disease, diabetes mellitus, cardiovascular disease, and cancer. Given the intricate relationship SIRT1 holds with a host of signal transduction pathways ranging from transcription factors, such as forkhead, to cytokines and growth factors, such as erythropoietin, it becomes critical to elucidate the cellular pathways of SIRT1 to safely and effectively develop and translate novel avenues of treatment for multiple disease entities.
Corresponding author: Kenneth Maiese, MD, e-mail: wntin75 yahoo. Gheorghita, Cornelia Amalinei, Irina-Draga Caruntu The protein capsid L1 of the human papilloma virus HPV - a key factor in the cervical carcinogenesis - is considered, together with p16, EGFR and COX-2, a characteristic marker for the evaluation of the malignancy progression and prognostic, in terms of tumoral aggressiveness.
Antigenul specific prostatic (PSA)
The purpose of the present study was to make a comparative assessment between the immunohistochemical pattern of p16, EGFR and COX-2 and immunochemical expression of L1 HPV capsid protein, in low grade and high-grade cervical squamous intraepithelial lesions, in order to determine the relationship of these tumoral markers with the infection status of HPV, and their practical applicability in patients diagnosis and follow-up.
Immunochemical detection of L1 capsid protein, on cervico-vaginal smears, indicates an immune status induced by the HPV infection and may offer prognosis information, mainly in LSIL lesions.
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Identifying molecular features for prostate cancer with Gleason 7 based on microarray gene expression profiles Loredana Balacescu, O. Balacescu, N. Crisan, B. Fetica, B. Meurice, Al. Irimie, N. Dragos, Ioana Berindan-Neagoe Prostate cancer represents the first leading cause of cancer among western male population, with different clinical behavior ranging from indolent to metastatic disease. Although many molecules and deregulated pathways are known, the molecular mechanisms involved in the development of prostate cancer are not fully understood.
Cancerul de Prostata
The aim of this study was to explore the molecular variation underlying the prostate cancer, based on microarray analysis and bioinformatics approaches. Normal and prostate cancer tissues were collected by macrodissection from prostatectomy pieces.
All prostate cancer specimens used in our adenocarcinoma prostate gleason 33 were Gleason score 7. The bioinformatics and functional analysis were based on Limma and Ingenuity software.
The microarray analysis identified differentially expressed genes between prostate cancer and normal prostate, which were up- or down-regulated at least 2-fold. P-values were adjusted for multiple testing using Benjamini-Hochberg method with a false discovery rate of 0.
These genes were analyzed with Ingenuity Pathway Analysis software and were established 23 genetic networks. Our microarray results provide new information regarding the molecular networks in prostate cancer stratified as Gleason 7.
These data highlighted gene expression profiles for better understanding of prostate cancer progression. Corresponding author: Ovidiu Balacescu, PhD, e-mail: obalacescu yahoo. Data regarding the possible association between ischemic stroke and the polymorphism of methylenetetrahydropholate reductase MTHFR CT and AC are still conflictual. Aim: The study tried to assess the association of the two MTHFR polymorphisms with ischemic stroke in a series of patients from a unique hospital center.
Materials and Methods: The adenocarcinoma prostate gleason 33 comprised a total of patients 67 with non-cardioembolic ischemic stroke diagnosed hematurie prostatita computed tomography or magnetic resonance imaging and 60 control cases. The method we used was reverse hybridization performed on peripheral blood for CT and AC polymorphisms. In all patients a careful clinical examination, laboratory analyses of cholesterol, glucose amount and triglycerides, as well as their medical history were available.
Results: The mean age of stroke patients was No statistically significant correlations of the two genotypes with infarct localization and dimensions ant with other potential risk factors hypertension, lipids, diabetes mellitus were observed.
However, they could be rather involved in hemorrhagic stroke, as seen in our control patients. Further evaluation on larger series is mandatory since homocysteine activity related to MTHFR activity could be easily influenced by folate or cobalamin derivatives.
Sonoelastography of breast lesions: a prospective study of cases with histopathological correlation Ioana Andreea Gheonea, Liliana Donoiu, D. Camen, Florina Carmen Popescu, Simona Bondari Background: Elastography adenocarcinoma prostate gleason 33 an imaging technique, which displays the hardness of soft tissue, by showing the behavior of tissue when subjected to mechanical stress.
The purpose of this study was to assess the role of ultrasound elastography in differential diagnosis of breast lesions. We introduced in this prospective study patients diagnosed with breast lesions between January and January The patients were examined in adenocarcinoma prostate gleason 33 supine position and a ductal exploration was made over the breast. Adenocarcinoma prostate gleason 33 final diagnose was cytology FNA - fine needle aspirationhistology after excision or follow-up for six months.
For assessment of ultrasound elastography role in differential diagnosis of breast lesions, we performed ROC analysis. Results: The elasticity score for benign lesions was on average 1. The mean diameter of malignant lesions was The most common histology of the benign nodules was fibroadenomas, cysts, and fibrocystic change.
PROSTATE CANCER: What's my prognosis? - Grade, Stage, PSA, Gleason score and novel genomic assays
Of the malignant nodules, the most common lesion was infiltrative ductal carcinoma. We obtained a sensitivity of Conclusions: Elastography is a method which can complement conventional ultrasound by improving the diagnostic performance.
The introduction of ductal ultrasound combined with elastography increased the sensitivity and specificity, the radial technique allowing the precise localization of lesions regarding the breast gland.
Correlation between histopathological form and the degree of neuroendocrine differentiations in prostate cancer Elena Viorica Bocan, O. Mederle, Simona Sarb, R. Minciu, D. Agapie, M. The aim of this study was to investigate the neuroendocrine component of the prostatic carcinoma, in relation to the histopathological form and the degree of differentiation.
Biopsies were obtained through transurethral resection, from 82 patients with prostate cancer. In order to assess the histopathological form and the Gleason score, one section from each case was stained with Hematoxylin-Eosin.
Scopul depistarii precoce a cancerului de prostata este identificarea cancerului intr-un moment in care tratamentul este cel mai probabil eficient. Riscul de deces din cauza cancerului de prostata este semnificativ in cazul tumorilor de grad moderat sau crescut. Acest lucru este valabil mai ales la barbatii mai tineri.
Additional sections were stained with chromogranin A. Cells positive for chromogranin A have been identified in all the cases, but a larger number than that registered in normal tissue has been noted in 59 patients In most of the cases, the neuroendocrine cells have been distributed in small groups among the neoplasic cells, and rarely isolated. In two cases of small cell carcinoma most of the tumoral cells have been positive for chromogranin A.
In conclusion, the study of neuroendocrine differentiation in patients with prostatic carcinoma revealed hyperplasia of positive chromogranin A cells, in Neuroendocrine prostatic differentiation is correlated with the advanced stage of evolution and possibly with the resistance to hormonal treatment.
Renal subcapsular tertiary lymphoid aggregates in chronic kidney diseases E. Mandache, M. Penescu In the last decade, adenocarcinoma prostate gleason 33 has been accepted the formation of tertiary lymphoid organs in the renal parenchyma during inflammatory conditions.
These organized cellular aggregates contain B- and T-lymphocytes, dendritic cells, surrounded by neo-lymphatic vessels.
They have been described in renal allografts, acute and chronic interstitial nephritis, IgA and membranous nephropathies. The functional characteristics of these lymphoid nodules remained still under consideration. After investigating the renal biopsies of patients with primary and secondary nephropathies, we have selected 20 cases showing lymphoid-like cellular aggregates located just beneath the renal capsule and having close contacts with this kidney envelope.
All of these cases also showed an associated medium sized lymphatic vessel. The ultrastructure of these nodules proved to contain more or less the same cellular composition: lymphocytes, dendritic cells, seldom plasma cells and macrophages. We consider these particular subcapsular lymphoid-like nodules to adenocarcinoma prostate gleason 33 tertiary lymphatic structures in close association with the perirenal lymphatics, and the first to develop in any type of inflammatory and autoimmune renal condition.
VEGF and his R1 and R2 receptors expression in mast cells of oral squamous cells carcinomas and their involvement in tumoral angiogenesis Raluca Ciurea, Cl. Margaritescu, Cristiana Simionescu, A. Stepan, M. This study included 60 cases of oral squamous carcinoma processed by usual histological technique and stained with Hematoxylin-Eosin and Alcian Blue-Safranin Alcian Blue powder from Sigma Aldrich, code AG and diagnosed in the Department of Pathology, University of Medicine and Pharmacy of Craiova.
Double immunohistochemical-histochemical reactions allowed us angiogenic profiling the mast cells. This study has highlighted the importance of mast cells in the tumor vânătăi din prostatită of the oral squamous carcinomas, especially in terms of their proangiogenic profile expression of VEGF and its R1 and R2 receptors. In addition, their quantification as MDM makes this parameter a useful prognostic marker. Osteonecrosis of the jaws associated with the use of bisphosphonates.
Discussion over 52 cases H. Almasan, Mihaela Baciut, H. Rotaru, S. Bran, Oana Cristina Almasan, G. Baciut Background: Osteonecrosis of the jaws is increasing worldwide in patients treated with bisphosphonates. Study design: Adenocarcinoma prostate gleason 33 retrospective review of 52 patients who were treated during for bisphosphonate related maxillofacial symptoms of the jaws was conducted.
Patient characteristics and other factors that influenced the disease process were studied. Results: Thirteen patients received bisphosphonates for the prevention or treatment of osteoporosis; 39 for preventing bone metastases from malignant tumors.
Thirty-six patients were females age range years, median 64 years ; 16 were males age range adenocarcinoma prostate gleason 33, median Bisphosphonate used was ibandronic acid adenocarcinoma prostate gleason 33 four cases, alendronate sodium in 14 cases, and zoledronic acid in 34 cases.
Mean bisphosphonate treatment period was Thirty patients received intravenous, 22 received oral bisphosphonate. The average period until occurrence of maxillofacial symptoms was 6 months range 0. Conclusions: The risk of bisphosphonate related osteonecrosis of the jaws is very high twelve months after oral administration and six months after intravenous administration in patients who have a trigger point in the jaws area. A proper monitoring of patients receiving bisphosphonates can reduce the risk of osteonecrosis and can prevent complications.
Discussion over 52 cases PDF Alecu, Ana-Gabriela Benghiac, L. Zetu, Codrina Ancuta, E. Ancuta, A. Nemtoi, Cristina Iordache Background: Recent advances have suggested that periodontitis PDthe paradigm of chronic infection in dental pathology, shares several pathogenic pathways with cardio- and cerebro-vascular disorders CVDbased on inflammatory mediators including IL-1, IL-6, TNF-alpha.
The predefined assessment protocol has included: current medical data, risk factors for CRP changes, periodontal status clinical, orthopantomography, Schei Ruler techniqueinflammatory biomarkers CRP, IL Mogoanta Stroke is an important public health issue because it has high morbidity and mortality rates. In addition, it has one of the highest rates of disability in adults. Recent data show that macrophage system cells, adenocarcinoma prostate gleason 33 microglial cells, are involved both in neuroprotective processes and in the neurotoxicity, depending on the type and extent of the brain damage.
In our study, using histology and immunohistochemistry techniques, we evaluated the macrophage-type cell reaction in cerebral hemorrhage.
We found that the number of CDpositive cells increased folds per square millimeter of cortical surface in the cerebral parenchyma adjacent to the hemorrhage.
- Antigenul specific prostatic (PSA)
- There is a discrepancy in the Gleason score given on the initial biopsy and prostatectomy specimen, respectively, that affects both patients who can benefit from active surveillance and those who cannot benefit from curative surgical treatment, and for whom therapeutic alternatives must be established.
- Se consideră că beneficiul terapie de privare androgenica TDA incipiente este incert și trebuie echilibrat cu riscul efectelor secundare ale TDA.
- Cancerul Prostatei | Centru Oncologie Severin
We identified a large number of perivascular-activated macrophages, in areas distant to the hemorrhage, showing that individuals with hemorrhagic stroke have profound and extensive alterations of the blood-brain barrier. Scanning electron microscopic observation of morphological modifications produced by Fluorostom on enamel surface Cristina Nicolae, Mihaela Hincu, C.
Amariei In this in vitro study, examination of the morphological changes of enamel surface after topical application of a sodium fluoride solution was performed. Validation of the Fluorostom effectiveness became possible, after 10 years of using for the caries prevention national program. Materials and Methods: Sound human enamel sections, ware treated with a 0.
The demineralization areas were immersed in mL of sodium fluoride solution, twice daily for 30 days. Surface examination was performed at scanning electron microscope and energy dispersion spectrometry. Results: Morphological appearance of fluoride deposits on the enamel surface revealed the presence of globular precipitates.
EDX qualitative analysis revealed the presence of fluoride signals. Conclusions: Globular structures adenocarcinoma prostate gleason 33 amorphous CaF2 precipitates, which act as a fluoride reservoir, were observed on the enamel surface after action of Fluorostom, and it can be recommended to prevent and control tooth decay. Expression of CCL18 and interleukin-6 in the plasma of breast cancer patients as compared with benign tumor patients and healthy controls Diana Narita, E.
Seclaman, S. Ursoniu, R. Ilina, Natalia Cireap, A. Anghel A growing body of laboratory research has shown that pro-inflammatory cytokines can facilitate tumor growth and metastasis. Our goal știri despre prostatită to quantify the expression adenocarcinoma prostate gleason 33 CCL18 and IL-6 in patients with breast cancer compared with benign breast tumors patients and healthy women, in order to evaluate if these cytokines could serve for breast cancer diagnosis and evaluation.
We also correlated the cytokines level of expression with some clinical and pathological characteristics known as prognostic markers for breast cancer.
Plasma samples were obtained before treatment from 58 breast cancers, 41 benign breast tumors and 30 healthy women. Wilcoxon test was used to compare groups. The plasma from benign breast tumor patients exhibited also significant higher levels of the two cytokines than normal controls.
The cytokines profile was not linked to patient age, tumor size, histopathological type, lymph node status or histological grade. IL-6 was significantly upregulated in ER-positive and metastasized cancers.